ADARs, APOEBECS, and tumours: RNA Editing and Disease Manifestations

Time: 3:10 pm
day: Day Two

Details:

  • Discussing how RNA editing can clearly alter disease manifestations, but there are bottlenecks with regards to efficiency and specificity
  • Exploring RNA editing enzymes (ADARs and APOEBECs) that are prominently expressed in most tumours (vs healthy tissues)
  • Can we target these to HLA-presented epitopes toward apparent neoepitope formation (and T-cell clearance?)

Speakers: