Flipons, Editing and Cancer

Time: 1:30 pm
day: Day Two


  • Understanding how in addition to the recoding of proteins, RNA editing regulates biological responses by modifying RNAs encoded by repeat elements
  • Highlighting with ADAR1, the process is targeted by flipons that form Z-RNA in regions of dsRNA, preventing interferon induction
  • Discussing tumors that produce excess dsRNAs use ADAR1 to inhibit interferondriven immune responses against them
  • Exploring targeting of Z-flipon recognition by ADAR1 represents a novel therapeutic intervention to enhance immune checkpoint blockade