Harnessing Endogenous ADAR for Oligo-Directed RNA Editing
• The OPERA platform (Oligonucleotide Promoted Editing of RNA), which utilizes synthetic oligonucleotides that recruit ADARs to repair disease-causing mutations at the RNA level
• In addition to repairing standard G-to-A mutations, our platform enables the modulation of protein function by changing the amino acid code
• Updates on the OPERA platform and progress towards the clinic