Leaper 2.0: Next Generation of Leveraging Endogenous ADAR for Programmable Editing on RNA

Time: 1:10 pm
day: Day One


  • Exploring how LEAPER edits RNA by recruiting endogenous ADAR proteins through double stranded RNA structure formed between arRNA and the specific sequence in the target RNA
  • Showcasing how in LEAPER 2.0, specific elements have been engineered to significantly improve the on-target editing efficiency
  • Understanding how additional designs have been developed to reduce the bystander off-target editing events