Structure-Guided Optimization of ADAR-Guiding Oligonucleotides

• High resolution structures of ADAR-RNA complexes solved by X-ray crystallography and cryo-EM

• Describing the impact of specific nucleoside analogs at different positions in ADAR guide strands

• Shedding light on the mechanism of the ADAR deamination reaction and informing the design of highly efficient and selective ADAR guide strand for therapeutic editing using chemically modified RNA

Speakers:

Peter Beal

Professor

University of Calfornia Davis