Brian Booth

Brian Booth

Company: Shape Therapeutics

Job title: Director of Platform Technologies


Enhanced gRNA Expression & Recruitment of Endogenous ADAR to Drive Robust RNA Editing in vivo 11:45 am

AAV delivery may result in low transduction efficiency in vivo, particularly in the CNS Robust expression of DNA-encoded gRNAs is required to drive sufficient editing for therapeutic purposes We have engineered novel regulatory elements derived from the snRNA family to enhance expression and achieve high levels of editing in vivoRead more

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